In order to determine stability and reaction of durum wheat promising genotypes in dry and warm region of Iran, 18 durum wheat promising lines in 5 stations including Khorramabad, Ahvaz, Darab, Dezful and Zabul, along with commercial bread wheat and Karkheh cultivars as checks, based on randomized complete block design (RCBD), with three replications and two croping season (2007-2009) were evaluated. To evaluate genotype-environment interaction and determine of stable genotypes, ten stability statistics were calculated (bi, S2di, R2i, Di, DI, Si , PEGi, qi ,q(i) and GAI). Based on the results of the above statistics genotypes 1, 3, 5, 14, 16 and 17 in most methods showed varying degrees of the general stability. In general, genotypes 3 (AJAIA_12/F3LOCAL (SEL.ETHIO.135.85)//...), 5 (NUS / SULA / / 5 * NUS/4/SULA/RBCE_ ...), 14 (CNDO / PRIMADUR / / HAI-OU_17/3/SN TURK MI83-84 375 /...) and 16 (ADAMAR_15//ALBIA_1/ALTAR 84/3/SN TURK MI83-84..) with the average yield of 6.009, 5.926, 5.912 and 6.186 tons per hectare, respectively, had a better general stability and adaptability, consequently, these genotypes are advisable for dry and warm climate in Iran.